Synaptic Bloom - Brain-Gut Support Supplement
Feed your microbes the polyphenols your plate misses.
A daily polyphenol supplement made to work alongside a plant-rich diet. It adds more of the plant compounds your gut microbes turn into support for steady focus, smooth digestion, and healthy circulation.
Each serving delivers 200 mg of Quercetin alongside a full spectrum of polyphenols from wild blueberries, cranberries, pomegranate, grapes, broccoli extract, and Japanese pagoda tree flower buds. Three small capsules, once a day, with the meals you're already eating.
Supported by decades of brain-gut-microbiome research from Dr. Emeran Mayer, and by peer-reviewed studies you can read here.
Supports:
- Focus and mental clarity
- Healthy cognitive function and memory
- A resilient gut microbiome
- Healthy circulation and cardiovascular function
According to the CDC, 90% of Americans don't get enough fruits and vegetables. Food comes first. Synaptic Bloom is built to add to a diet full of plants, giving your microbes a steady daily supply of polyphenols on top of what's on your plate.
30-day supply, 90 vegetarian capsules
$2.00 a day, or $1.67 a day when you subscribe
Why Dr. Mayer recommends this
"I have spent my career studying how the gut, the brain and the microbiome talk to each other. Polyphenols are one of the clearest levers we have, and the dose matters. That is why every ingredient here is listed with its exact amount."
Emeran Mayer, MD
Gastroenterologist and neuroscientist · Distinguished Research Professor, David Geffen School of Medicine at UCLA
Bundle & Save
The Polyphenol Pair
Pair Synaptic Bloom with our EVOO for two simple, everyday sources of polyphenols: three capsules with your meals, and a drizzle of oil on them.
Buy them together and save $14.99.
Regular Price: $99.98 | Bundle Price: $84.99
Polyphenols come from a wide variety of plants, and variety is the part most diets miss. Synaptic Bloom brings six sources into one daily serving, so your microbes get a consistent supply whatever the week looks like.
What's in every serving
Proprietary blends can hide how much of each ingredient you're actually getting. Synaptic Bloom lists every ingredient and its exact amount, right on the label.
- Standardized quercetin
- 200 mg
- Per 3-capsule serving
- Actives per serving
- 1,100 mg
- Across seven label ingredients
- Daily serving
- 3 capsules
- 90 vegetarian capsules, a 30-day supply
- Free from
- Dairy, gluten, soy, GMOs
- Vegan formula
Amounts are per 3-capsule serving, as printed on the Synaptic Bloom label.
Everything on the label
Every ingredient, every amount, exactly as printed on the bottle. No hidden blends, nothing left out.
200 mg standardized quercetin
Supplement Facts
| Amount Per Serving | % Daily Value |
|---|---|
| Wild blueberry blendCanadian wild blueberries (Vaccinium angustifolium Ait., Vaccinium angustifolium ssp nigrum, Vaccinium myrtilloides) (berry) | 200 mg * |
| Cranberry extractVaccinium macrocarpon (fruit) | 200 mg * |
| Pomegranate polyphenol extractPunica granatum (fruit) | 200 mg * |
| Quercetin | 200 mg * |
| Broccoli blendBroccoli powder extract (Brassica oleracea L.) (seed), mustard powder (Sinapis alba) (seed) | 100 mg * |
| Red grape powder (Vinia®)Vitis vinifera (cells) (with polyphenols and piceid resveratrol) | 100 mg * |
| Vitamin E isomers (DeltaGold®)As delta and gamma tocotrienols from annatto (Bixa orellana) (seed) | 100 mg * |
*Daily Value not established.
† This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
DeltaGold® is a registered trademark of American River Nutrition, LLC and protected by US Patent 8,586,109. Vinia® is a registered trademark of BioHarvest, Ltd.
How It's Made
Synaptic Bloom is manufactured in a GMP registered facility in the USA from US and globally sourced ingredients.
Good Manufacturing Practices
GMP is the FDA's standard for how a supplement is actually produced: verified ingredient identity, controlled and documented batch processes, sanitation and equipment requirements, and records that trace any batch back through production. It is the difference between a facility that follows a defined process every time and one that does not.
Named, Standardized Ingredients
DeltaGold tocotrienols and Vinia red grape powder are branded, standardized ingredients, not unspecified extracts. You can look up what they are and what they contain.
Exact Amounts, Every Batch
Every ingredient appears with its exact amount. No proprietary blend, no "and other ingredients," no way for the dose to quietly change between batches.
What to Look for in a Polyphenol Supplement
Not all of them give you the same information. Here is what we think matters, and where Synaptic Bloom stands.
Committed to Science, Not Trends
Wellness has been overtaken by influencers and self-proclaimed gurus, most of them working without a scientific foundation. Meanwhile the real research on the brain-gut connection, polyphenols, and the microbiome sits locked in academic journals where almost no one reads it.
Mayer Nutrition exists to close that gap. Founded by Dr. Emeran Mayer, a gastroenterologist and neuroscientist who has spent his career studying the links between the gut, brain, and microbiome, alongside Dylan Mayer, MS, whose background is in neuroscience, nutrition, and human performance.
Every product is research-driven, built on ingredient integrity, and transparent by design. You should know exactly what you are putting in your body.
Making It Part of Your Day
Take It With a Meal
Three capsules, once a day, with whichever meal you are least likely to skip. There is no particular time of day that works better, so pick the one that will stick.
Food Still Comes First
Synaptic Bloom is built to add to a diet full of plants, not replace one. Keep eating the produce you already eat. This fills the gaps on the weeks when variety slips.
Give It a Few Weeks
Polyphenols work gradually through your microbiome. Most people take it consistently for several weeks before noticing a difference, so treat it as a daily habit rather than something you feel right away.
Frequently Asked Questions
The questions we get most, answered properly.
What does Synaptic Bloom actually do?
It gives your gut microbes a daily supply of polyphenols, the plant compounds they turn into support for steady focus, smooth digestion, and healthy circulation. Each serving delivers 200 mg of standardized quercetin alongside a full spectrum of polyphenols from six plant sources.
Isn't this just what fruits and vegetables do?
Yes, and food comes first. According to the CDC, 90% of Americans don't get enough fruits and vegetables. Synaptic Bloom is built to add to a diet full of plants, not replace one. If you already eat a wide variety of produce every day, you are getting much of this already.
Why quercetin, and why 200 mg?
Quercetin is one of the most widely studied polyphenols. The amount here is standardized at 200 mg per three-capsule serving, so you get the same dose every single day. Plenty of blends list quercetin without saying how much is in there, which makes it impossible to know what you are actually taking.
How long before I notice anything?
Give it time. Polyphenols work gradually through your microbiome, so this is a daily habit rather than something you feel the first afternoon. Most people take it consistently for several weeks before noticing a difference. That is also why the subscription exists, since the people who get the most from it are the ones who stay with it.
How do I take it?
Three capsules once a day, with a meal. There is no particular time of day you need to take them, so pair them with whichever meal you are least likely to skip. One bottle holds 90 vegetarian capsules, a 30-day supply.
Can I take it with my medications or other supplements?
Talk to your doctor or pharmacist before starting, particularly if you take prescription medication, are pregnant or nursing, or are managing a health condition. That is standard guidance for any supplement, and we would rather you ask than guess.
What quality standards is it made to?
Synaptic Bloom is manufactured in a GMP registered facility in the USA from US and globally sourced ingredients. Good Manufacturing Practices are the FDA's standards covering ingredient identity, batch controls, sanitation and traceability, so every capsule is produced to the same documented process. Every ingredient and its exact amount is printed on the label.
Why does it cost more than polyphenol supplements at the drugstore?
Standardized doses instead of a proprietary blend, named branded ingredients like DeltaGold and Vinia rather than an unspecified powder, and no fillers. A cheaper bottle usually tells you what is in it but not how much, which is the part that decides whether it does anything. This works out to $2.00 a day, or $1.67 a day on subscription.
How fast will I get it, and what if something is wrong?
Orders are processed within 1 to 2 business days and you will get tracking as soon as it ships. Standard delivery runs 3 to 7 business days, with expedited options available at checkout. We ship worldwide.
If your bottle arrives damaged, or if it is marked delivered and never shows up, email hello@mayernutrition.com within 7 days and we will sort it out. Same if you receive the wrong item. Include your order number and a photo if you have one.
Is it vegan, and what is it free from?
Yes, it is a vegan formula in vegetarian capsules, and it is free from dairy, gluten, soy and GMOs. The full ingredient list, with the exact amount of each one, is on the label and on this page.
What if I want to change or cancel my subscription?
You are in control of it. Skip a delivery, reschedule it, change what you receive, or cancel entirely, whenever you want. There is no minimum number of orders and no phone call required.
Real People, Real Reviews
- MAMary A. V. A.Verified BuyerRated 5 out of 5 stars1 month agoSo Much More ENERGY
Okay, first, I love the way this smells like berries! And I have TONS more energy, which by itself would be enough - but also my digestion is improved - and MOST of all, BRAIN FOG is gone. I haven't heard anyone else talking about it, but now, after about 6 weeks, I've had FAR less struggle to find words [so important for this writer] a much higher ability to remember aspects of difficult tasks, and even a better outlook! I keep a pretty specific journal on brain health, and this is the only change I've made in the last couple of months ... so grateful! I'm gifting this to everyone I love.
Mayer Nutrition1 month agoThanks for your review, Mary! We are so happy to hear this!
- MFMoe F.Verified ReviewerRated 5 out of 5 stars1 year agoBeat supplement
I've been using the Polyphenol Blend supplement for a few months now, and the results have been outstanding! From the very first week, I noticed a significant boost in my energy levels and overall vitality. My digestion has improved, and I feel less bloated after meals. The antioxidant support has done wonders for my skin, giving it a healthier, radiant glow. I also appreciate that it's made from high-quality, natural ingredients with no artificial additives. This blend has genuinely enhanced my wellness routine, and I highly recommend it to anyone looking to support their health naturally.
Mayer Nutrition1 year agoThanks, Moe! We're glad that SB is helping you out!
- AGAdam G.Rated 5 out of 5 stars1 year agoA Game-Changer for My Busy Workdays
I’ve been juggling a demanding work schedule and often don’t have time to prepare balanced meals with enough fruits and vegetables. Synaptic Bloom has been a game-changer—it gives me peace of mind knowing I’m filling in the nutritional gaps on busy days. I feel more energized, focused, and healthier overall. Perfect for anyone who wants better nutrition without the hassle.
Mayer Nutrition1 year agoThis is great to hear, Adam! Thanks for the review!
- MPMichael P.Verified ReviewerRated 5 out of 5 stars1 year agoGut Health Finally Hacked
I chose Synaptic Bloom because it’s made with all-natural ingredients and zero fillers. Before discovering it, I had no idea what polyphenols were or how important they are to overall health. After a month of consistent use, I’ve noticed significant improvements in my gut health and overall well-being. It’s become an easy and valuable part of my daily routine!
Mayer Nutrition1 year agoRight on, Michael! We're glad to hear it's helping you out!
- KLKristen L.Verified ReviewerRated 5 out of 5 stars1 year agoPolyphenol Blend
Coming from someone who wasn't totally positive on what a polyphenol was (micronutrients with antioxidant properties), I truly love this blend. One small bowl of blueberries, a handful of grapes & cranberries, a third of a pomegranate + a serving of broccoli all in one - what really got me with this product is that it supports your health across multiple systems (supports gut, brain, heart health andddd fills in nutritional gaps for those that don't always get their daily intake of polyphenols that are needed/missing in your normal diet). Big fan!
Mayer Nutrition6 minutes agoThanks, Kristen! Disclosure: Kristen received a complimentary bottle.
You May Also Like
