The Science Behind the Brand
Mayer Nutrition is built on the landmark work of Dr. Emeran Mayer, a gastroenterologist and neuroscientist who has spent his career studying how the gut, the brain and the microbiome influence one another. Most of that research sits in academic journals where almost nobody reads it. Dr. Mayer and Dylan Mayer, MS, whose background is in neuroscience, nutrition and human performance, founded the company to change that. Every product starts from that research, and every ingredient appears on the label with its exact amount.
Emeran Mayer, MD, Co-Founder and Scientific Advisor, is a gastroenterologist, neuroscientist, and Distinguished Research Professor at the David Geffen School of Medicine at UCLA. He is founding director of the Goodman-Luskin Microbiome Center and the author of The Mind-Gut Connection and The Gut-Immune Connection.
Read our storySTART EATING FOR YOUR MICROBES
Your Gut Is Home to Trillions of Living Microbes
What you eat shapes what they do. Here's how it works.
90%
According to the CDC, about 9 in 10 American adults don't eat the recommended amount of fruits and vegetables, the main dietary sources of polyphenols.
1,000+ mg
Research associates higher polyphenol intake, often above 1,000 mg a day, with healthy cardiovascular function, cognitive performance and a balanced gut microbiome. Most people get far less.
Trillions
The gut is home to trillions of bacteria, an ecosystem shaped by diet that supports brain, immune and metabolic health. These microbes break polyphenols down into compounds the body can absorb and use.
What Are Polyphenols?
Polyphenols are naturally occurring plant compounds found in colorful fruits, vegetables, tea and cocoa. They're best known as antioxidants, but research suggests they do much more.
Support brain health. Quercetin and other flavonoids have been studied for their role in supporting memory, focus and cognitive performance, including in older adults. Some polyphenols also support healthy blood flow to the brain.
Support cardiovascular health. In clinical studies, quercetin has been linked to healthy blood vessel function and circulation, and to maintaining blood pressure already within a healthy range. Diets rich in polyphenols are consistently associated with heart health.
Support gut health and microbial balance. Polyphenols interact with gut bacteria, encouraging the growth of beneficial species and the production of short-chain fatty acids, which help maintain a healthy gut lining.
Together, polyphenols support communication within the brain-gut-microbiome system, which plays a central role in long-term health.
Learn MoreFrequently Asked Questions
Quick answers about Synaptic Bloom, polyphenols and your order. For everything else, visit our full FAQ page.
What are polyphenols, and why do they matter for the gut?
Polyphenols are plant compounds found in colorful fruits, vegetables, tea, cocoa and olive oil. Many of them reach the large intestine, where gut microbes break them down into compounds the body can absorb and use. That is why Dr. Mayer's work focuses on feeding your microbes, not just you.
How do I take Synaptic Bloom?
Three capsules once a day, with a meal. There is no particular time of day you need to take them, so pair them with whichever meal you are least likely to skip. One bottle holds 90 vegetarian capsules, a 30-day supply.
What quality standards is Synaptic Bloom made to?
It is manufactured in a GMP registered facility in the USA from US and globally sourced ingredients. Every ingredient and its exact amount is printed on the label, with no proprietary blends and no fillers.
How does the subscription work, and can I cancel?
You are in control of it. Skip a delivery, reschedule it, change what you receive, or cancel entirely, whenever you want. There is no minimum number of orders and no phone call required.
What is your shipping and return policy?
Orders are processed within 1 to 2 business days, and you will get tracking as soon as it ships. Standard delivery runs 3 to 7 business days. Because supplements are ingestible, we cannot accept returns on opened products. If your order arrives damaged, never shows up or is the wrong item, email hello@mayernutrition.com within 7 days and we will sort it out.
What Customers Are Saying
Adam G.
“I often don’t have time to prepare balanced meals with enough fruits and vegetables. Synaptic Bloom… gives me peace of mind knowing I’m filling in the nutritional gaps on busy days.”
Glenn S., Verified Reviewer
“I’ve always been a skeptic about supplements… Within about five days I started noticing more consistent level of energy and definitely sharper focus… One of the biggest changes has been the lack of that usual mid-afternoon crash.”
Carly, Verified Reviewer
“I’m a current third year medical student doing rotations and sometimes it is hard to find the time to eat enough fruits & vegetables. Synaptic Bloom has been a major help for getting in more polyphenols.”
Received a complimentary bottle.
Alison S., Verified Buyer
“As a nurse I look carefully at labels and appreciate the clean contents without any weird additives. I’ve followed Dr Mayer for a while and find I can trust his products to support my gut.”
Chelsea, Verified Reviewer
“After reading The Mind Gut Connection… I’ve been looking for legitimate ways to support my gut health and this supplement checks all the boxes. I really appreciate the science backed ingredient list.”
Received a complimentary bottle.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.